IL18 molecular target information overview
Overview of IL18 molecular targets
Interleukin 18 (IL-18), also known as interferon gamma-inducing factor, is a pro-inflammatory cytokine encoded by the IL18 gene in humans. IL-18 belongs to the IL-1 superfamily and is secreted by macrophages and other cells. After IL-18 stimulation, natural killer (NK) cells and certain T cells release another important cytokine, interferon gamma or type II interferon, which in turn activates macrophages or other cells. IL-18 can induce a severe inflammatory response and can also increase the production of beta-amyloid protein (associated with Alzheimer's disease) in human neurons.
Human IL18 Molecular Target Information
Molecular name: IL18, interleukin 18
Alias:
- iboctadekin
- IFN-gamma-inducing factor
- IGIF
- IL-1 gamma
- IL-18
- IL-1g
- IL1F4
- interferon gamma-inducing factor
- interleukin 18 (interferon-gamma-inducing factor)
- interleukin-1 gamma
- interleukin-18
- MGC12320
Gene sequence:NCBI_Gene: 3606
Protein sequence: UniProtKB: Q14116
Human IL18 target molecular function (prediction)
Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).
Mouse Il18 molecular target information
Molecular name: Il18, interleukin 18
Alias:
- Igif
- Il-18
- interferon gamma inducing factor
Gene sequence:NCBI_Gene: 16173
Protein sequence:
- UniprotKB: P70380
- UniprotKB: A0A1L1STF5
- UniprotKB: A0PJ18
- UniprotKB: K3W4N2
- UniprotKB: Q2PMY2
- UniprotKB: Q6USQ6
- UniprotKB: Q80SS8
Mouse Il18 target molecular function (prediction)
Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).
Rat Il18 molecular target information
Molecular name: Il18, interleukin 18
Alias:
- IFN-gamma-inducing factor
- IL-1 gamma
- IL-18
- interferon gamma-inducing factor
- interferon-gamma-inducing factor
- interleukin-1 gamma
- interleukin-18
Gene sequence:NCBI_Gene: 29197
Protein sequence:
Rat Il18 target molecular function (prediction)
Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; (multiple); perinatal necrotizing enterocolitis; and urinary tract infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).