IL17_MOUSE Q62386
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UniProt:Q62386
Recommended name：Interleukin-17A
EC number：
Alternative names：(IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)
Cleaved into：
GeneID：16171
Gene names (primary )：Il17a
Gene names (synonym )：Ctla8 Il17
Gene names (ORF )：
Length：158
Mass：17490
Sequence：MSPGRASSVSLMLLLLLSLAATVKAAAIIPQSSACPNTEAKDFLQNVKVNLKVFNSLGAKVSSRRPSDYLNRSTSPWTLHRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPESCPFTFRVEKMLVGVGCTCVASIVRQAA
Tissue specificity：Expressed by Th17 cell lineage (at protein level). The expression pattern reflects the differentiation state, with IL17A-IL17F heterodimers produced at higher levels than IL17A-IL17A and IL17F-IL17F dimers in fully differentiated Th17 cells (PubMed:18025225, PubMed:16990136). Expressed in innate lymphoid cells (at protein level) (PubMed:23255360, PubMed:28709803). Expressed in gamma-delta T cell subsets (at protein level) (PubMed:17372004, PubMed:20364087, PubMed:28709803, PubMed:26431948). Expressed in iNKT cells (at protein level) (PubMed:17470641). {ECO:0000269|PubMed:16990136, ECO:0000269|PubMed:17372004, ECO:0000269|PubMed:17470641, ECO:0000269|PubMed:18025225, ECO:0000269|PubMed:20364087, ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:26431948, ECO:0000269|PubMed:28709803}.
Induction：Induced upon differentiation of CD4-positive T cells toward Th17 effector cells upon antigen receptor binding in the presence of IL6 and TGFB1 (PubMed:16200068, PubMed:16990136, PubMed:18025225). Up-regulated by IL23A-IL12B, IL1B and TNF and inhibited by IFNG and IL4 (PubMed:16200068, PubMed:18025225). Up-regulated by proinflammatory cytokines in response to microbes in various immune cells: induced in innate lymphoid cells upon fungal infection, in Vdelta4-positive gamma-delta T cells upon C. mastitidis infection, in Vdelta5-positive gamma-delta T cells upon S. aureus infection and in Vdelta1-positive gamma-delta T cells upon E. coli infection (PubMed:23255360, PubMed:28709803, PubMed:20364087, PubMed:17372004). Induced in gamma-delta T cells in intestinal lamina propria upon acute injury (PubMed:26431948). Induced in KLRB1/NK1.1-negative iNKT cell subset upon CD1D stimulation (PubMed:17470641). {ECO:0000269|PubMed:16200068, ECO:0000269|PubMed:16990136, ECO:0000269|PubMed:17372004, ECO:0000269|PubMed:17470641, ECO:0000269|PubMed:18025225, ECO:0000269|PubMed:20364087, ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:26431948, ECO:0000269|PubMed:28709803}.
Developmental stage：
Protein families：IL-17 family