MEPE_MOUSE Q8K4L6
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q8K4L6
Recommended name：Matrix extracellular phosphoglycoprotein
EC number：
Alternative names：(Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin)
Cleaved into：
GeneID：94111
Gene names (primary )：Mepe
Gene names (synonym )：
Gene names (ORF )：
Length：441
Mass：46872
Sequence：MTPEGLMKMQAVSVGLLLFSMTWAAPMPNEDRSSCGNQDSIHKDLAASVYPDPTVDEGTEDGQGALLHPPGQDRYGAALLRNITQPVKSLVTGAELRREGNQEKRPQSVLSVIPADVNDAKVSLKDIKNQESYLLTQSSPVKSKHTKHTRQTRRSTHYLTHLPQIKKTPSDLEGSGSPDLLVRGDNDVPPFSGDGQHFMHIPGKGGAGSGPESSTSRPLSGSSKAEVIDPHMSGLGSNEIPGREGHGGSAYATRDKAAQGAGSAGGSLVGGSNEITGSTNFRELPGKEGNRINAGSQNAHQGKVEFHYPQVASREKVKGGVEHAGRAGYNEIPKSSKGSSSKDAEESKGNQLTLTASQRFPGKGKSQGPALPSHSLSNEVKSEENHYVFHGQNNLTPNKGMSQRRGSWPSRRPNSHRRASTRQRDSSESSSSGSSSESHGD
Tissue specificity：Expressed in osteocytes (at protein level) (PubMed:12421822, PubMed:15221418). Expressed by chondrocytes, specifically in the hypertrophic zone of the bone growth plate (at protein level) (PubMed:22766095). Expressed in osteoblasts in bone (at protein level) (PubMed:11414762, PubMed:15221418, PubMed:18597632). Expressed by osteoblasts within the metaphysis (at protein level) (PubMed:15221418, PubMed:22766095). Expressed at low levels in white fat, brown fat, testes, brain and aorta (PubMed:12421822). Expressed in the craniofacial complex (at protein level) (PubMed:26927967). Expressed in odontoblasts, ameloblasts and in predentin during tooth development (at protein level) (PubMed:22042093). Expressed in the kidney (at protein level) (PubMed:26051469). Expressed in osteocytes in mandibular condylar cartilage and tibial cartilage (at protein level) (PubMed:26428891). Expressed in salivary glands (PubMed:15329369). {ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:12421822, ECO:0000269|PubMed:15329369, ECO:0000269|PubMed:18597632, ECO:0000269|PubMed:22042093, ECO:0000269|PubMed:22766095, ECO:0000269|PubMed:26051469, ECO:0000269|PubMed:26428891, ECO:0000269|PubMed:26927967}.
Induction：Induced by ascorbate and beta-glycerophosphate (PubMed:11414762, PubMed:12421822). Induced expression during bone fracture healing, with low levels of expression being detected in fibroblast-like cells at 6 days post-fracture, and increased expression at 10 days post-fracture in late hypertrophic chondrocytes. At 14 days post-fracture, expression is detected in osteocytes, osteoblasts, and hypertrophic chondrocytes. By 28 days post-fracture, expression was highest in osteocytes and lower in osteoblasts (PubMed:15221418). Down-regulated by 1-alpha-25-dihydroxyvitamin D3 (calcitriol) (PubMed:11414762). {ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:12421822, ECO:0000269|PubMed:15221418}.
Developmental stage：Detected at 16 days post coitum (dpc) in both epithelial and mesenchymal components of the tooth organ (PubMed:26927967). Also detected at 16 dpc and 18 dpc in mandibular bone osteocytes (PubMed:26428891). Detected at 15 dpc in the bone collar (PubMed:26428891). Detected at 13 dpc in the cartilage matrix (PubMed:26428891). Detected at postnatal day 3 in odontoblasts and ameloblasts (PubMed:22042093). At postnatal day 5, expression is decreased in dental papilla cells, but increased in the predentin (PubMed:22042093). By postnatal day 9, is only detected in the predentin (PubMed:22042093). Detected at postnatal day 2 in osteoblasts, the calcified cartilage cores in primary metaphyseal bone and in osterocytes embedded in cortical bone matrix (PubMed:15221418). At postnatal day 84 expression is detected in the osteocytes of cortical and trabecular bone (PubMed:15221418). {ECO:0000269|PubMed:15221418, ECO:0000269|PubMed:22042093, ECO:0000269|PubMed:26428891, ECO:0000269|PubMed:26927967}.
Protein families：PF07175/osteoregulin family