CLCN3_MOUSE P51791
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UniProt:P51791
Recommended name：H(+)/Cl(-) exchange transporter 3
EC number：
Alternative names：(Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)
Cleaved into：
GeneID：12725
Gene names (primary )：Clcn3
Gene names (synonym )：Clc3
Gene names (ORF )：
Length：818
Mass：90812
Sequence：MESEQLFHRGYYRNSYNSITSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKDILRHMAQTANQDPASIMFN
Tissue specificity：Detected in kidney, in the apical part of proximal tubule cells (at protein level). Expressed at high levels in the kidney while a low level expression is seen in the brain. Within the brain, it is prominent in the hippocampus, cerebral cortex and olfactory bulb. {ECO:0000269|PubMed:18923035, ECO:0000269|PubMed:7665160}.; [Isoform 1]: Brain, pancreas, kidney, liver, lung, retina, olfactory bulb, and spinal cord. {ECO:0000269|PubMed:26342074}.; [Isoform 2]: Brain, pancreas, kidney, liver, lung, retina, olfactory bulb, and spinal cord. {ECO:0000269|PubMed:26342074}.; [Isoform 3]: Pancreas, kidney, liver, lung and retina. {ECO:0000269|PubMed:26342074}.; [Isoform 4]: Brain, heart, pancreas, kidney, liver, lung, retina, olfactory bulb, and spinal cord. {ECO:0000269|PubMed:26342074}.; [Isoform 5]: Expressed at high levels in the liver and at low levels in the brain. {ECO:0000269|PubMed:24603049}.
Induction：
Developmental stage：At 10.5 days of development it is expressed throughout the embryo. Later in development (12.5 to 14.5 days of gestation), expression is progressively up-regulated in neurons of the brain and the spinal cord, in all cranial sensory ganglia and in the sympathetic dorsal root ganglia. {ECO:0000269|PubMed:7665160}.
Protein families：Chloride channel (TC 2.A.49) family, ClC-3/CLCN3 subfamily