LRGUK_MOUSE Q9D5S7
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UniProt:Q9D5S7
Recommended name：Leucine-rich repeat and guanylate kinase domain-containing protein
EC number：
Alternative names：
Cleaved into：
GeneID：74354
Gene names (primary )：Lrguk
Gene names (synonym )：
Gene names (ORF )：
Length：820
Mass：93190
Sequence：MAAFERNPSRWKGTRFRRGLGASRIAAQAILSLTEKQSQGRWPSFPLGLKSKGTFRSASSYLLHQLIHRSHEAEAEQEEKQQEDGESEESEESEMQNLEDKYDGILREETVAEAITGLGWSGRGTEQVYLNLNLSHCELVDISILCGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNKLTTFFNFKPPQNLKKVDFSSNLISEMYDLSAYHTLTQLILDNNEIEEITGLENCISLTHLSLAGNKITTIKGLGTLPIKVLSLSNNMIETITGLEELKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIYMLLRLTELDQQKIKVEEKVFAVNKYDPPPEVVAVQDHMTHVVNSMSQPQRIWDSTLPSLDAPYPMLILTGPAACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQEVFDEMLNMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNQKYPGYFDAVINADDMDIAYQKLSELIREYLGLTETAAKTLAPTADTKTSYLKCEDYSRKSSTVEFLDSTDRNYFTKLWAKLSSKKSPVERESLHRQHEAARQALMGKTPRDHTLLFQRGPVPIPTVSGQQYFATIDELQKTFELSDDLFKTPSGTYPETSKDSNISKRYSTYFHTCPWSKELPFQLPEGGISSRPGSAGSDEVDGALKALRVASSMQEKVAQHKRLSAITIMDPGSNTKPTLPPIPHGRR
Tissue specificity：Highly expressed in the testis (PubMed:25781171). During spermatid development is initially localised to a supra-nuclear region of round spermatids, and is particularly evident at the leading edge of the developing acrosome and acroplaxome. As maturation proceeded and nuclear elongation initiated, LRGUK moves distally to ultimately reside on the microtubules of the manchette. LRGUK is also evident in the sperm basal body and the sperm tail (PubMed:25781171). {ECO:0000269|PubMed:25781171}.
Induction：
Developmental stage：Detectable at low levels from birth, up-regulated at day 14 coincident with the appearance of pachytene spermatocytes, then maximal from day 18 coincident with the appearance of haploid germ cells (PubMed:25781171). {ECO:0000269|PubMed:25781171}.
Protein families：