BHA15_MOUSE Q9QYC3
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UniProt:Q9QYC3
Recommended name：Class A basic helix-loop-helix protein 15
EC number：
Alternative names：(bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)
Cleaved into：
GeneID：17341
Gene names (primary )：Bhlha15
Gene names (synonym )：Bhlhb8 Mist1
Gene names (ORF )：
Length：197
Mass：22150
Sequence：MKTKNRPPRRRTPMQDTEATPGEQTPDRPQSGSGGSELTKGLRSRTARASGGRGEVSRRRQGSGGRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAMLGVTEDQPQGHLQRYSTQIHSFREGS
Tissue specificity：Expressed in pancreatic tissue only in acinar cells. There is a complete absence of expression in intra- or interlobular pancreatic ducts and in all islet cells. {ECO:0000269|PubMed:11696558}.
Induction：Up-regulated by XBP1. Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin and thapsigargin, and also by glucose starvation (PubMed:17612490).
Developmental stage：First observed at 10.5 dpc in the primitive gut and in the developing lung bud. Expression in the gut persists through 16.5 dpc and remains restricted primarily to the epithelial lining of the esophagus, stomach and intestine. Expression in the lung is detected in the bronchial epithelium at 14.5 dpc and at 15.5 dpc. Expressed specifically in acinar cells during pancreatic development. Detected in skeletal muscle tissues beginning at 12.5 dpc, persisting throughout all embryonic stages examined although, in older embryos expression becomes severely reduced. {ECO:0000269|PubMed:9073453}.
Protein families：