MP2K7_MOUSE Q8CE90
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UniProt:Q8CE90
Recommended name：Dual specificity mitogen-activated protein kinase kinase 7
EC number：EC 2.7.12.2
Alternative names：(MAP kinase kinase 7) (MAPKK 7) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
Cleaved into：
GeneID：26400
Gene names (primary )：Map2k7
Gene names (synonym )：Mkk7
Gene names (ORF )：
Length：535
Mass：59312
Sequence：MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPTRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYEILEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFSTSVTWGAWPLAAQTPFQSGVIRCRGRVPSPRRATGGSGGQPCVCAGGPGPSFTEMGPSPSPMLSNTFFTPDPGACPGASTWGLPRRRLCQLLTTSTPGCC
Tissue specificity：Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen. {ECO:0000269|PubMed:9312105, ECO:0000269|PubMed:9405446, ECO:0000269|PubMed:9535930}.
Induction：
Developmental stage：Expressed at high levels in the brain, spinal cord, eyes, muscle, lungs, vertebrae, and intestine and at lower levels in the heart and livers at 12.5 dpc. At later stages of embryogenesis (14.5 dpc, 16.5 dpc, and 18.5 dpc) high levels were found in the brain, retina, bone marrow, skin, intestine, lung epithelium and the epithelial layers lining the olfactory cavity and developing teeth and whiskers. {ECO:0000269|PubMed:9405446}.
Protein families：Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily