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IL5 molecular target information overview


  • Molecular name: IL5, interleukin 5
  • Gene family: Interleukins
  • Alias: IL-5; EDF; TRF
  • Alias: interleukin-5; 5 (colony-stimulating factor, eosinophil)


    • Overview of IL5 molecular targets


    Interleukin 5 (IL-5) is a member of the hematopoietic family of Th2 cytokines and consists of 115 amino acids. Unlike other members of the cytokine family (IL-3 and GM-CSF), the activated form of this glycoprotein is a homodimer. IL-5 is secreted by Th2 cells and mast cells. Its biological activity on B cells and other types of cells indicates that IL-5 has an important functional role in the activity of Th2 cells. IL-5 stimulates B cell growth and increases immunoglobulin secretion by binding to its receptor. It is also a key factor in activating eosinophils. IL-5 has been associated with a variety of allergic diseases, including allergic rhinitis and asthma. A significant increase in IL-5 was observed in circulating tissues and tracheal tissues, while sputum eosinophils decreased.


    Human IL5 molecular target information


    Molecular name: IL5, interleukin 5


    Alias:

    • B cell differentiation factor I
    • B-cell differentiation factor I
    • colony-stimulating factor, eosinophil
    • EDF
    • eosinophil differentiation factor
    • IL-5
    • interleukin-5
    • T-cell replacing factor
    • TRF

    Gene sequence:NCBI_Gene: 3567

    Protein sequence: UniProtKB: P05113


    Human IL5 target molecular function (prediction)


    Predicted to enable cytokine activity; growth factor activity; and interleukin-5 receptor binding activity. Involved in positive regulation of podosome assembly. Located in extracellular region. Implicated in asthma. Biomarker of several diseases, including Churg-Strauss syndrome; Henoch-Schoenlein purpura; arthritis (multiple); asthma (multiple); and lymphoid leukemia (multiple).


    Mouse Il5 molecular target information


    Molecular name: Il5, interleukin 5


    Alias:

    • Il-5


    Gene sequence:NCBI_Gene: 16191

    Protein sequence:


    Mouse Il5 target molecular function (prediction)


    Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of immunoglobulin production; and positive regulation of transcription, DNA-templated. Acts upstream of or within positive of peptidyl-tyrosine phosphorylation. Located in extracellular regulation space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5).


    Rat Il5 molecular target information


    Molecular name: Il5, interleukin 5

    Alias:

    • B-cell growth factor II
    • BCGF-II
    • cytotoxic T-lymphocyte inducer
    • eosinophil differentiation factor
    • IL-5
    • Interleukin 5 (colony-stimulating factor eosinophil)
    • Interleukin 5 (colony-stimulating factor, eosinophil)
    • interleukin-5
    • T-cell replacing factor
    • TRF

    Gene sequence:NCBI_Gene: 24497

    Protein sequence:


    Rat Il5 target molecular function (prediction)


    Enables cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5).