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MMP9 molecular target information overview


  • Molecular name: MMP9, matrix metallopeptidase 9
  • Gene family: M10 matrix metallopeptidases
  • Former name: CLG4B
  • Alias: matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)


    • Overview of MMP9 molecular targets


    Matrix metalloproteinase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B, is a class of enzymes belonging to the zinc-metalloproteinase family. MMP-9 is involved in the degradation of the extracellular matrix in normal physiological processes (such as embryonic development, reproduction, angiogenesis, bone development, wound healing cell migration, learning and memory) and pathological processes (such as arthritis, cerebral hemorrhage and tumor metastasis). MMP-9 and elastase appear to be regulators of neutrophil migration through the basement membrane. MMP-9 plays an important role in angiogenesis and neovascularization. It is significantly upregulated during the healing process of human airway epithelium and has been found to be associated with many pathological processes such as cancer, immune and cardiovascular diseases. MMP-9 levels have been found to be elevated in cases of rheumatoid arthritis and focal cerebral ischemia. Its levels increase with the development of idiopathic atrial fibrillation.


    Human MMP9 molecular target information


    Molecular name: MMP9, matrix metallopeptidase 9


    Alias:

    • 92 kDa gelatinase
    • 92 kDa type IV collagenase
    • CLG4B
    • GELB
    • macrophage gelatinase
    • MANDP2
    • matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    • matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    • matrix metalloproteinase-9
    • MMP-9
    • type V collagenase

    Gene sequence:NCBI_Gene: 4318

    Protein sequence:UniProtKB: P14780


    Human MMP9 target molecular function (prediction)


    Enables identical protein binding activity; metalloendopeptidase activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of apoptotic signaling pathway; and positive regulation of keratinocyte migration. Located in extracellular space. Implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); brain disease (multiple); carcinoma (multiple); and lung disease (multiple).


    Mouse Mmp9 molecular target information


    Molecular name: Mmp9, matrix metallopeptidase 9


    Alternate names:

    • AW743869
    • B/MMP9
    • Clg4b
    • collagenase IVB, basement membrane, 92 kDa
    • expressed sequence AW743869
    • Gel B
    • Gelatinase B
    • gelatinase B
    • MMP-9


    Gene sequence:NCBI_Gene: 17395

    Protein sequence:


    Mouse Mmp9 target molecular function (prediction)


    Enables metalloendopeptidase activity. Involved in negative regulation of epithelial cell differentiation involved in kidney development and response to amyloid-beta. Acts upstream of or within several processes, including collagen catabolic process; embryo implantation; and extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central system; early conceptus; limb mesenchyme; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).


    Rat Mmp9 molecular target information


    Molecular name: Mmp9, matrix metallopeptidase 9

    Synonyms:

    • 92 kDa gelatinase
    • 92 kDa type IV collagenase
    • 92-kDa type IV collagenase
    • gelatinase B
    • GELB
    • matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
    • matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
    • matrix metalloproteinase-9
    • MMP-9

    Gene sequence:NCBI_Gene: 81687

    Protein sequence:


    Rat Mmp9 target molecular function (prediction)


    Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).