PITX3_MOUSE O35160
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UniProt:O35160
Recommended name：Pituitary homeobox 3
EC number：
Alternative names：(Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)
Cleaved into：
GeneID：18742
Gene names (primary )：Pitx3
Gene names (synonym )：
Gene names (ORF )：
Length：302
Mass：31715
Sequence：MEFGLLGEAEARSPALSLSDAGTPHPPLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGGFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGAPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVPGPPPAANLSPCQYAVERPV
Tissue specificity：Highly expressed in developing eye lens. Expression is restricted to the substantia nigra and ventral tegmental area in the midbrain. {ECO:0000269|PubMed:15950611, ECO:0000269|PubMed:19007884}.
Induction：
Developmental stage：First visible in 10.5 dpc embryos where expression is confined to the lens vesicles. Between 11.5 dpc and 12.5 dpc, expressed in both the lens epithelium and differentiating primary fiber cells. In the late fetal stage after the lens is formed, primarily found in the lens epithelium and the lens equator region where lens epithelial cells exit from the cell cycle and differentiate into fiber cells (at protein level). First expressed in the eye at 10 dpc embryos. Throughout eye development, expressed in the lens placode and forming lens pit. From 12 dpc, also detected in the midbrain region, tongue, incisor primordia, condensing mesenchyme around the sternum and vertebrae and in the head muscles. {ECO:0000269|PubMed:19007884, ECO:0000269|PubMed:9620774}.
Protein families：Paired homeobox family, Bicoid subfamily