COL12_MOUSE Q8K4Q8
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UniProt:Q8K4Q8
Recommended name：Collectin-12
EC number：
Alternative names：(Collectin placenta protein 1) (CL-P1) (Scavenger receptor with C-type lectin)
Cleaved into：
GeneID：140792
Gene names (primary )：Colec12
Gene names (synonym )：Clp1 Srcl
Gene names (ORF )：
Length：742
Mass：81304
Sequence：MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIVLLYILCALLTITVAILGYKVVEKMDNVTDGMETSHQTYDNKLTAVESDLKKLGDQAGKKALSTNSELSTFRSDILDLRQQLQEITEKTSKNKDTLEKLQANGDSLVDRQSQLKETLQNNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQSQMYSQSVVIMNLNNLNLTQVQQRNLISNLQQSVDDTSLAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLSSFTGQMDNITTISQANEQSLKDLQDLHKDTENRTAVKFSQLEERFQVFETDIVNIISNISYTAHHLRTLTSNLNDVRTTCTDTLTRHTDDLTSLNNTLVNIRLDSISLRMQQDMMRSKLDTEVANLSVVMEEMKLVDSKHGQLIKNFTILQGPPGPRGPKGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGTIGPVGPPGERGSKGSKGSQGPKGSRGSPGKPGPQGPSGDPGPPGPPGKDGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAMEPLALQNEPTPASEVNGCPPHWKNFTDKCYYFSLEKEIFEDAKLFCEDKSSHLVFINSREEQQWIKKHTVGRESHWIGLTDSEQESEWKWLDGSPVDYKNWKAGQPDNWGSGHGPGEDCAGLIYAGQWNDFQCDEINNFICEKEREAVPSSIL
Tissue specificity：Expressed in vascular endothelial cells in the heart, in perivascular macrophage and smooth muscle cells. Expressed in plaques-surrounding reactive astrocytes located in cerebral cortex and hippocampus and in leptomeningeal vessels showing characteristics of cerebral amyloid angiopathy (CAA) in a double transgenic mouse model of Alzheimer disease (at protein level). Strongly expressed in lung. Moderately expressed in heart, skeletal muscle, spleen, liver, brain, colon, testis, stomach and kidney. Expressed in neonatal astrocytes. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of a double transgenic mouse model of Alzheimer disease. {ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:11718900, ECO:0000269|PubMed:16868960}.
Induction：Up-regulated in activated microglia and by fibrillar amyloid-beta peptide in activated astrocytes. {ECO:0000269|PubMed:16868960}.
Developmental stage：Expressed in embryo at 9 dpc, increases progressively to a peak at 14 dpc and gradually decreases until 19 dpc. {ECO:0000269|PubMed:11718900}.
Protein families：