ZFP42_MOUSE P22227
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UniProt:P22227
Recommended name：Zinc finger protein 42
EC number：
Alternative names：(Zfp-42) (Reduced expression protein 1) (REX-1) (mREX-1)
Cleaved into：
GeneID：22702
Gene names (primary )：Zfp42
Gene names (synonym )：Rex-1 Rex1
Gene names (ORF )：
Length：288
Mass：32398
Sequence：MNEQKMNEQMKKTAKTSGQKGPGGRALDRLTLKQDEARPVQNTRVEAPRVTYTIRDESEISPETEEDGFPDGYLECIIRGEFSEPILEEDFLFKSFESLEEVEQNLSRQVLEASSLLESSLEYMTKGTKQEKTEVTQETPPLRVGASSLLAGGPAEKPEGGVYCGVLSMLECPQAGCKKKLRGKTALRKHMLVHGPRRHVCAECGKAFTESSKLKRHFLVHTGEKPYQCTFEGCGKRFSLDFNLRTHIRIHTGERRFVCPFDGCEKSFIQSNNQKIHILTHAKAGKKC
Tissue specificity：Restricted to testis, to germ cells in the early stages of spermatogenesis. Not expressed in spermatids, nor spermatozoa. Expressed in embryonic stem (ES) cells. {ECO:0000269|PubMed:15749260, ECO:0000269|PubMed:16908534, ECO:0000269|PubMed:16960129, ECO:0000269|PubMed:1821852}.
Induction：Up-regulated by NANOG, up-regulation which is increased by SOX2 and POU5F1. Up-regulated by nicotine; up-regulation which is prevented with tubocurarine, a nicotinic acetylcholine receptor antagonist. Down-regulated by sodium vanadate and retinoic acid (RA). In ES cells, down-regulation correlates with differentiation. {ECO:0000269|PubMed:15749260, ECO:0000269|PubMed:16714766, ECO:0000269|PubMed:16908534, ECO:0000269|PubMed:1821852, ECO:0000269|PubMed:2511439}.
Developmental stage：Expressed in the inner cell mass of 4.5 dpc blastocysts, as well as in the polar trophoblast. At 6 dpc, abundant in the extraembryonic ectoderm and the ectoplacental cone. At this stage, not detected in the embryonic ectoderm. At 7 dpc, restricted to the extraembryonic ectoderm and the ectoplacental cone. Also expressed in the placenta. Expressed in male germ cells undergoing meiosis. {ECO:0000269|PubMed:1821852}.
Protein families：Krueppel C2H2-type zinc-finger protein family