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IGFBP7 molecular target information overview


  • Molecular name: IGFBP7, insulin like growth factor binding protein 7
  • Gene family: I-set domain containing
  • Alias: MAC25; IGFBP-7; PSF; FSTL2
  • Alias: insulin-like growth factor binding protein 7


    • IGFBP7 molecular targets review


    The superfamily of insulin-like growth factor (IGF) binding proteins includes six high-affinity IGF binding proteins (IGFBPs) and at least four other low-affinity binding proteins, termed IGFBP-related proteins (IGFBP-rPs). IGFBP7 is a low-affinity IGF binding protein that plays an integral role in regulating the actions of insulin-like growth factor (IGF) in a variety of cell types, including stimulation of prostacyclin production and cell adhesion. Some IGFBPs may also have intrinsic biological activities that are independent of their ability to bind IGF proteins. IGFBP7 levels have been associated with the development of cancer. Loss of IGFBP7 expression has been associated with poor survival and tumor chemotherapy resistance in a variety of cancer types. IGFBP7 has also been identified as a cell cycle arrest biomarker for acute kidney injury in humans and as a prognostic indicator for the development of early acute kidney injury.


    Human IGFBP7 molecular target information


    Molecular name:IGFBP7, insulin like growth factor binding protein 7


    Alias:

    • AGM
    • angiomodulin
    • FSTL2
    • IBP-7
    • IGF-binding protein 7
    • IGFBP-7
    • IGFBP-7v
    • IGFBP-rP1
    • IGFBPRP1
    • insulin-like growth factor binding protein 7
    • insulin-like growth factor-binding protein 7
    • MAC25
    • PGI2-stimulating factor
    • prostacyclin-stimulating factor
    • PSF
    • RAMSVPS
    • TAF
    • tumor-derived adhesion factor

    Gene sequence:NCBI_Gene: 3490

    Protein sequence:UniProtKB: Q16270


    Human IGFBP7 target molecular function (prediction)


    Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cell adhesion. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix.


    Mouse Igfbp7 molecular target information


    Molecular name:Igfbp7, insulin-like growth factor binding protein 7


    Alternate names:

    • AGM
    • follistatin-like 2
    • Fstl2
    • mac25


    Gene sequence:NCBI_Gene: 29817

    Protein sequence:


    Mouse Igfbp7 target molecular function (prediction)


    Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).


    Rat Igfbp7 molecular target information


    Molecular name:Igfbp7, insulin-like growth factor binding protein 7

    Alias:

    • insulin-like growth factor-binding protein 7
    • LOC289560

    Gene sequence:NCBI_Gene: 289560

    Protein sequence:


    Rat Igfbp7 target molecular function (prediction)


    Predicted to enable insulin-like growth factor binding activity. Involved in several processes, including embryo implantation; response to cortisol; and response to retinoic acid. Located in extracellular space. Biomarker of renal cell carcinoma. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).