SEM4F_MOUSE Q9Z123
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UniProt:Q9Z123
Recommended name：Semaphorin-4F
EC number：
Alternative names：(Semaphorin-W) (Sema W)
Cleaved into：
GeneID：20355
Gene names (primary )：Sema4f
Gene names (synonym )：Semaw
Gene names (ORF )：
Length：777
Mass：84490
Sequence：MLARAERPRPGPRPPPVSLFPPPSSLLLLLLAMLSAPVCGRVPRSVPRTSLPISEADSYLTRFAAPHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPETQPVESMKLYHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQPSGVTSLTPRRDGLEVVVTPGAMGAYACECQEGGAARVVAAYSLVWGSQRGPANRAHTVVGAGLVGFFLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKRGSGFGGFPPPFLLDSCPSPAHIRLTGAPLATCDETSI
Tissue specificity：Expressed throughout the adult brain, where it shows particularly strong expression in the hippocampus, corpus callosum, granular layer and deep nuclei of the cerebellum, and the mitral layer of the olfactory bulb (at protein level) (PubMed:21945643). At the cellular level, detected in neuronal precursors, postmitotic neurons, pyramidal neurons, and glial cells including mature oligodendocytes and oligodendroglial precursor cells (at protein level) (PubMed:21945643). {ECO:0000269|PubMed:21945643}.
Induction：
Developmental stage：During 14 dpc expression is abundant in the cerebral cortex, hippocampus, brain stem and the mitral and glomerular layers of the olfactory bulb, expression in the olfactory bulb remains evident into adulthood (at protein level) (PubMed:21945643). Expressed in proliferative layers and oligodendroglial precursor cells (OPCs) during embryonic development (14-16 dpc), in regions such as the ganglionic eminence, mamillothalamic tract, neuroepithelium, and cortical plate (at protein level) (PubMed:21945643). Expressed in migrating OPCs along the optic nerve at 16.5 dpc (at protein level) (PubMed:21945643). During late embryonic development (18 dpc) expression is abundant in pyramidal and granular cells of the hippocampus, and OPCs in the migratory pathway and embryonic fimbria of the hippocampus (at protein level) (PubMed:21945643). At postnatal day 1 (P1) expression is abundant in the corpus callosum, anterior commissure, and several nerve nuclei in the hindbrain, such as the oculomotor nucleus, the periaqueductal gray area, the facial nucleus, the colliculli, and the raphe and pararubral nuclei, as well as in the proliferative layers of the anterior subventricular zone, with expression remaining evident into adulthood (at protein level) (PubMed:21945643). A significant abundance of protein is apparent in the arcuate and posterior hypothalamic nuclei at P10, and additionally in hypothalamic OPCs, expression becomes evident in the arcuate nucleus at P15 (at protein level) (PubMed:21945643). Abundant expression throughout the embryonic brain from 14 dpc onwards with decreased expression in all areas of the brain in adulthood, however expression remains relatively abundant (PubMed:21945643). {ECO:0000269|PubMed:21945643}.
Protein families：Semaphorin family