IL7 molecular target information overview
Overview of IL7 molecular targets
Interleukin 7 (IL-7) is a hematopoietic growth factor secreted by bone marrow and thymic stromal cells. It can also be produced by keratinocytes, dendritic cells, hepatocytes, neurons and epithelial cells, but normal lymphocytes cannot produce IL-7. IL-7 stimulates the differentiation of multipotent hematopoietic stem cells into lymphoid progenitor cells, and also stimulates the proliferation of all lymphoid cells (B cells, T cells and NK cells). IL-7 promotes the development of malignant hematological diseases (acute lymphoblastic leukemia, T-cell lymphoma). Elevated IL-7 levels have been detected in the plasma of HIV-infected patients. IL-7 can also improve immune recovery after allogeneic stem cell transplantation.
Human IL7 Molecular Target Information
Molecular name: IL7, interleukin 7
Alias:
- IL-7
- IL7 nirs variant 6
Gene sequence:NCBI_Gene: 3574
Protein sequence:UniProtKB: P13232
Human IL7 target molecular function (prediction)
Enables cytokine activity. Involved in cytokine-mediated signaling pathway; positive regulation of chemokine production; and positive regulation of cytokine-mediated signaling pathway. Located in extracellular region. Part of collagen-containing extracellular matrix. Implicated in epidermodysplasia verruciformis. Biomarker of Alzheimer's disease and COVID-19.
Mouse Il7 molecular target information
Molecular name: Il7, interleukin 7
Alias:
- A630026I06Rik
- heart, lung and blood 368
- hlb368
- Il-7
- RIKEN cDNA A630026I06 gene
Gene sequence:NCBI_Gene: 16196
Protein sequence:
Mouse Il7 target molecular function (prediction)
Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of lymphocyte activation; and tissue homeostasis. Located in extracellular space. Is expressed in several structures, including brain; branchial arch; hemolymphoid system; intestine; and lymphatic system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7).
Rat Il7 molecular target information
Molecular name: Il7, interleukin 7
Alias:
- IL-7
- interleukin-7
Gene sequence:NCBI_Gene: 25647
Protein sequence:
Rat Il7 target molecular function (prediction)
Predicted to enable cytokine activity and growth factor activity. Involved in cellular response to hypoxia and response to X-ray. Predicted to be located in extracellular space. Used to study high grade glioma. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7).