TRI18_MOUSE O70583
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UniProt:O70583
Recommended name：E3 ubiquitin-protein ligase Midline-1
EC number：EC 2.3.2.27
Alternative names：(Midin) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
Cleaved into：
GeneID：17318
Gene names (primary )：Mid1
Gene names (synonym )：Fxy Trim18
Gene names (ORF )：
Length：680
Mass：76136
Sequence：METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMSSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQRRQIIGTKIKEGKVIRLRKLAQQIANCKQCLERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPAIREELCTASYDTITVHWTSEDEFSVVSYELQYTIFTGQANVVNVACDGTCLLGSAGLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFTVKAINQAGSRSSEPGKLKTNSQPFRLDPKSAHRKLKVSHDNLTVERDESSSKKSHAPERFAGQGSYGVAGNVFIDSGRHYWEVVTSGSTWYAIGLAYRSAPKHEWIGKNAASWALCRCHNHWAVRHDGKETPIAPAPHLRRVGVLLDYDNGSIAFYDALSSVHLHTFHAALAQPVCPTFTVWNKCLTIVTGLPIPDHLDCTEQRP
Tissue specificity：Ubiquitously expressed in fetus and adult. At 9 dpc-10.5 dpc, highest expression found in frontonasal processes, branchial arches and CNS. From 12.5 dpc to 16.5 dpc, high levels found in rostral part of CNS. At 14.5 dpc, begins to be highly expressed in kidney and lung. At 16.5 dpc, highly expressed in the mucosa of the hindgut and cutaneous region of the stomach. {ECO:0000269|PubMed:9722948}.
Induction：
Developmental stage：Expressed throughout embryonic development with highest levels from 7-11 dpc. Also expressed in the adult. {ECO:0000269|PubMed:9722948}.
Protein families：TRIM/RBCC family