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KDR molecular target information overview


  • Molecular name: KDR, kinase insert domain receptor
  • Gene family: Receptor tyrosine kinases; CD molecules; V-set domain containing; I-set domain containing
  • Alias: FLK1; VEGFR; VEGFR2; liver kinase 1; kinase insert domain receptor (a type III receptor tyrosine kinase)


    • Overview of KDR molecular targets


    Vascular endothelial growth factor receptor 2 (VEGFR2), also known as kinase insert domain receptor (KDR), is a member of the class III subfamily of tyrosine kinase receptors (RTKs). Compared with VEGFR1, VEGFR2 is more widely expressed in endothelial cells derived from blood vessels. VEGFR2 binds to VEGF-A (VEGF121, VEGF165, VEGF189 and VEGF206 splice variants), VEGF-C and VEGF-D. Soluble VEGFR1 and VEGFR2 differ significantly in blocking VEGF-induced cell proliferation and migration. In contrast to soluble VEGFR1, soluble VEGFR2 is unable to compete with VEGF and binds to endothelial cells expressing VEGFR1 and VEGFR2. Soluble VEGFR2 can only partially inhibit cell migration, while soluble VEGFR1 almost completely blocks VEGF-induced cell proliferation and migration. The binding of VEGF to soluble VEGFR2 but not to VEGFR1 is also dependent on heparin. The VEGF/VEGFR2 signaling pathway plays an important role in tumorigenesis and other diseases with pathological angiogenesis. Inactivation of functional VEGFR2 using blocking antibodies can disrupt angiogenesis and prevent the spread of tumor cells.


    Human KDR Molecular Target Information


    Molecular name: KDR, kinase insert domain receptor


    Alias:

    • CD309
    • fetal liver kinase 1
    • fetal liver kinase-1
    • FLK1
    • kinase insert domain receptor (a type III receptor tyrosine kinase)
    • protein-tyrosine kinase receptor Flk-1
    • soluble VEGFR2
    • tyrosine kinase growth factor receptor
    • vascular endothelial growth factor receptor 2
    • VEGFR
    • VEGFR2

    Gene sequence:NCBI_Gene: 3791

    Protein sequence:UniProtKB: P35968


    Human KDR target molecular function (prediction)


    Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of mitochondrial depolarization; and positive regulation of mitochondrial fission. Located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); glioblastoma; macular degeneration (multiple); scleroderma (multiple).


    Mouse Kdr molecular target information


    Molecular name: Kdr, kinase insert domain protein receptor


    Alias:

    • fetal liver kinase 1
    • Flk-1
    • Flk1
    • orv
    • orvieto
    • vascular endothelial growth factor receptor- 2
    • VEGF receptor-2
    • VEGFR-2
    • VEGFR2


    Gene sequence:NCBI_Gene: 16542

    Protein sequence:


    Mouse Kdr target molecular function (prediction)


    Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adheions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple);


    Rat Kdr molecular target information


    Molecular name: Kdr, kinase insert domain receptor

    Alias:

    • fetal liver kinase 1
    • FLK-1
    • FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
    • FLK1 kinase insert domain receptor (VEGF receptor 2)
    • kinase insert domain protein receptor
    • MGC93590
    • protein-tyrosine kinase receptor flk-1
    • vascular endothelial growth factor receptor 2
    • Vegfr-2

    Gene sequence:NCBI_Gene: 25589

    Protein sequence:


    Rat Kdr target molecular function (prediction)


    Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including generation of neurons; positive regulation of endothelial cell proliferation; and positive regulation of intracellular signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).