IFNG molecular target information overview

IFNG molecular target information overview


  • Molecular name: IFNG, interferon gamma
  • Gene family: Interferons


    • Overview of IFNG molecular targets


    IFN-γ is mainly produced by Th1 cells and belongs to the interferon family of type II cytokines. It is a secretory glycoprotein composed of 143 amino acids and has a relative molecular mass of 16942. IFN-γ is mainly produced by activated T cells and NK cells. It has the functions of regulating the immune state of the body, mediating cellular immunity, strengthening receptor-mediated phagocytosis, enhancing the killing activity of macrophages and neutrophils, and has biological activities such as anti-viral infection and anti-tumor.


    Human IFNG molecular target information


    Molecular name: IFNG, interferon gamma


    Alias:

    • IFG
    • IFI
    • IFN-gamma
    • IMD69
    • immune interferon
    • interferon, gamma

    Gene sequence:NCBI_Gene: 3458

    Protein sequence:UniProtKB: P01579


    Human IFNG target molecular function (prediction)


    Predicted to enable cytokine activity. Involved in several processes, including positive regulation of cell death; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including positive of gene expression; positive regulation of protein phosphorylation; and response to virus regulation. Located in extracellular region. Implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; factor VIII deficiency; and leukemia (multiple). Biomarker of several diseases, including acute retinal necrosis syndrome; allergic rhinitis; autoimmune disease (multiple); nephritis (multiple); and otitis media (multiple).


    Mouse Ifng molecular target information


    Molecular name: Ifng, interferon gamma


    Alias:

    • Ifg
    • IFN-gamma


    Gene sequence:NCBI_Gene: 15978

    Protein sequence:


    Mouse Ifng target molecular function (prediction)


    Acts upstream of or within several processes, including CD8-positive, alpha-beta T cell differentiation involved in immune response; defense response to other organism; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; and nervous system. Used to study several diseases, including aplastic anemia; hepatitis; malaria; medulloblastoma; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; and leukemia (multiple). Orthologous to human IFNG (interferon gamma).


    Rat Ifng molecular target information


    Molecular name: Ifng, interferon gamma

    Alias:

    • If2f
    • IFN-gamma
    • IFNG2
    • interferon 2f

    Gene sequence:NCBI_Gene: 25712

    Protein sequence:


    Rat Ifng target molecular function (prediction)


    Predicted to enable cytokine activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of NMDA glutamate receptor activity; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; neuron projection; and perikaryon. Used to study several diseases, including Chagas disease; allergic conjunctivitis; allergic rhinitis; renal fibrosis; and ureteral obstruction. aneurysm; autoimmune thyroiditis; pulpitis; tongue squamous cell carcinoma; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; factor VIII deficiency; and leukemia (multiple). Orthologous to human IFNG (interferon gamma).

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