AUGN_MOUSE Q99LS0
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UniProt:Q99LS0
Recommended name：Augurin
EC number：
Alternative names：(Esophageal cancer-related gene 4 protein homolog)
Cleaved into：
GeneID：78896
Gene names (primary )：Ecrg4
Gene names (synonym )：
Gene names (ORF )：
Length：148
Mass：16992
Sequence：MSTSSARPAVLALAGLALLLLLCLGPDGISGNKLKKMLQKREGPVPSKTNVAVAENTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRNRNGHDYYGDYYQRHYDEDAAIGPHSRESFRHGASVNYNDY
Tissue specificity：Expressed in the intermediate lobe of pituitary, glomerular layer of adrenal cortex, choroid plexus and atrioventricular node of the heart (PubMed:17284679). Expressed in the brain with high expression in the choroid plexus and the epithelial lining of the central canal and expression in the gray matter of the spinal cord (at protein level) (PubMed:21349154). {ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:21349154}.
Induction：
Developmental stage：At embryonic stage 14.5 dpc, primarily expressed in the choroid plexus, and low expression in the heart and cartilage (at protein level) (PubMed:21349154). At 18.5 dpc, expressed in adrenal cortex, choroid plexus and bone (PubMed:17284679). Low expression in the brain of young, 2-month-old animals, except for the mitral cell layer of the olfactory bulb (PubMed:20404145). Strongly expressed in the brains of aged, 15- to 21-month-old mice with expression in the subgranular zone of the dentate gyrus and in the corpus callosum (at protein level) (PubMed:20404145). Also expressed in the CA1-3 regions of the hippocampus, as well as in the cerebellum, brainstem and cortex (PubMed:20404145). In vitro, up-regulated in senescent cells, including embryonic fibroblasts and oligodendrocyte precursor cells (PubMed:20404145). {ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:20404145, ECO:0000269|PubMed:21349154}.
Protein families：Augurin family