ZC12A_MOUSE Q5D1E7
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UniProt:Q5D1E7
Recommended name：Endoribonuclease ZC3H12A
EC number：EC 3.1.-.-
Alternative names：(Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)
Cleaved into：
GeneID：230738
Gene names (primary )：Zc3h12a
Gene names (synonym )：Mcpip Mcpip1
Gene names (ORF )：
Length：596
Mass：65598
Sequence：MSDPCGTKPVQESNPTMSLWSLEDRHSSQGRPQPDQDPVAKEAPTSELQMKVDFFRKLGYSSSEIHSVLQKLGVQADTNTVLGELVKHGSATERECQALTAPSPQPPLVPRGGSTPKPSTLEPSLPEEDREGSDLRPVVIDGSNVAMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVFTPSRRVGGKRVVCYDDRFIVKLAFESDGVVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPLPSEHRKQPCPYGKKCTYGIKCRFFHPERPSRPQRSVADELRANALLSPPRTPVKDKSSQRPSPASQSSSVSLEAEPGSLDGKKLGARSSPGPHREGSPQTCAPAGRSLPVSGGSFGPTEWLAHTQDSLPYTSQECLDSGIGSLESQMSELWGVRGGSPGESGPTRGPYAGYHSYGSKVPAAPSFSPFRPAMGAGHFSVPTDYVPPPPTYPSREYWSEPYPLPPPTPVLQEPQRPSPGAGGGPWGRVGDLAKERAGVYTKLCGVFPPHLVEAVMRRFPQLLDPQQLAAEILSYKSQHLSE
Tissue specificity：Expressed in CD4(+) helper T-cells (at protein level) (PubMed:29244194). Highly expressed in macrophages (PubMed:18178554). Expressed in lung, lymph nodes, spleen and thymus (PubMed:22037600). Expressed weakly in heart (PubMed:21616078). Expressed weakly in cardiomyocytes (at protein level) (PubMed:16574901). Expressed in spleen, lung, intestine, brown adipose tissue and thymus (PubMed:18682727). Weakly expressed in the heart (PubMed:16574901). Weakly expressed in cardiomyocytes (PubMed:16574901). {ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18178554, ECO:0000269|PubMed:18682727, ECO:0000269|PubMed:21616078, ECO:0000269|PubMed:22037600, ECO:0000269|PubMed:29244194}.
Induction：Up-regulated by the transcription factor KLF4 in a interleukin IL4-dependent manner in macrophage (PubMed:25934862). Up-regulated by lipopolysaccharide (LPS) (at protein level) (PubMed:21616078). Up-regulated by chemokine CCL2 during adipocytes differentiation (PubMed:19666473). Up-regulated in activated T lymphocytes (PubMed:23185455). Up-regulated in response to lipopolysaccharide (LPS) in a MyD88-dependent manner in macrophages (PubMed:18178554, PubMed:18682727, PubMed:19322177). Up-regulated by phorbol 13-acetate 12-myristate (PMA) in primary T lymphocytes (PubMed:23185455). Up-regulated by interleukin IL17 in keratinocytes (PubMed:26320658). {ECO:0000269|PubMed:18178554, ECO:0000269|PubMed:18682727, ECO:0000269|PubMed:19322177, ECO:0000269|PubMed:19666473, ECO:0000269|PubMed:21616078, ECO:0000269|PubMed:23185455, ECO:0000269|PubMed:25934862, ECO:0000269|PubMed:26320658}.
Developmental stage：
Protein families：ZC3H12 family