CR3L2_MOUSE Q8BH52
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UniProt:Q8BH52
Recommended name：Cyclic AMP-responsive element-binding protein 3-like protein 2
EC number：
Alternative names：(cAMP-responsive element-binding protein 3-like protein 2)
Cleaved into：Processed cyclic AMP-responsive element-binding protein 3-like protein 2
GeneID：208647
Gene names (primary )：Creb3l2
Gene names (synonym )：Bbf2h7
Gene names (ORF )：
Length：521
Mass：57469
Sequence：MEVLESGEQSVLQWDRKLSELSEPGETEALMYHTHFSELLDEFSQNVLGQLLSDPFLSEKSESMEVEPSPTSPAPLIQAEHSYSLSEEPRTQSPFTHAATSDSFNDEEVESEKWYLSTEFPSATIKTEPITEEQPPGLVPSVTLTITAISTPFEKEESPLDMNAGGDSSCQTLIPKIKLEPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSLSPNPRLHPFSLSQAHSPARAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLVAEGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHPLSEPYTASVVRSRNLLIYEEHAPLEESSSPASAGELGGWDRGSSLLRASSGLEALPEVDLPHFLISNETSLEKSVLLELQQHLVSSKLEGNETLKVVELERRVNATF
Tissue specificity：Widely expressed, including in lung, bladder, ovary, testis and spleen (PubMed:17178827). Highly expressed in chondrocytes (PubMed:19767744). {ECO:0000269|PubMed:17178827, ECO:0000269|PubMed:19767744}.
Induction：Up-regulated by ER stress at the transcript and protein levels, the increase at the protein level is much higher than at the transcript level. This induction is accompanied by increased proteolytic cleavage that releases the N-terminal transcription factor domain. Up-regulated in brain areas undergoing ischemic injury, in neurons, but not astrocytes. Up-regulated by SOX9 during chondrocyte differentiation, possibly through SOX9-induced mild ER stress (PubMed:19767744). {ECO:0000269|PubMed:17178827, ECO:0000269|PubMed:19767744}.
Developmental stage：
Protein families：BZIP family, ATF subfamily