IL17F_MOUSE Q7TNI7
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UniProt:Q7TNI7
Recommended name：Interleukin-17F
EC number：
Alternative names：(IL-17F)
Cleaved into：
GeneID：257630
Gene names (primary )：Il17f
Gene names (synonym )：
Gene names (ORF )：
Length：161
Mass：17941
Sequence：MKCTRETAMVKSLLLLMLGLAILREVAARKNPKAGVPALQKAGNCPPLEDNTVRVDIRIFNQNQGISVPREFQNRSSSPWDYNITRDPHRFPSEIAEAQCRHSGCINAQGQEDSTMNSVAIQQEILVLRREPQGCSNSFRLEKMLLKVGCTCVKPIVHQAA
Tissue specificity：Expressed by T-helper 17 cells (Th17) (at protein level). The expression pattern reflects the differentiation state. In fully differentiated Th17 cells, IL17A-IL17F heterodimers are produced at higher levels than IL17A-IL17A and IL17F-IL17F dimers (PubMed:18025225). Dominantly secreted in intestine (PubMed:29915298). Expressed by resident cells of the lamina propria, both epithelial cells and immune cell subsets including natural killer cells, dendritic cells, macrophages and various T and B cell subsets (PubMed:29915298, PubMed:16990136). Expressed by epithelial cells and innate immune cells in the colon (PubMed:19144317). Expressed in group 3 innate lymphoid cells (PubMed:23255360, PubMed:29915298). {ECO:0000269|PubMed:16990136, ECO:0000269|PubMed:18025225, ECO:0000269|PubMed:19144317, ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:29915298}.
Induction：Induced upon antigen receptor binding in the presence of IL6 and TGB1 (PubMed:16990136, PubMed:18025225). Up-regulated by IL23A-IL12B, IL1B and TNF and inhibited by IFNG and IL4 in CD4-positive T cells (PubMed:18025225). Induced upon fungal infection in innate lymphoid cells (PubMed:23255360). Induced in lung epithelial cells upon bacterial and fungal infection (PubMed:28813677). Induced in brown adipose tissue upon cold exposure (PubMed:32076265). {ECO:0000269|PubMed:16990136, ECO:0000269|PubMed:18025225, ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:28813677, ECO:0000269|PubMed:32076265}.
Developmental stage：
Protein families：IL-17 family