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FAS molecular target information overview


  • Molecular name: FAS, Fas cell surface death receptor
  • Gene family: CD molecules; Tumor necrosis factor receptor superfamily; Death inducing signaling complex
  • Alias: CD95;
  • Alias:TNF receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6)


    • Overview of FAS molecular targets


    Fas, also known as APO-1, CD95 or TNFRSF6, is a cell surface receptor that transduces apoptotic signals. It is one of two apoptotic pathways, the other being the mitochondrial pathway. Once bound to a ligand, Fas forms a death-inducing signaling complex. Membrane-anchored Fas ligand trimers on the surface of adjacent cells lead to Fas oligomerization. Recent studies in mouse models have shown that Fas promotes tumor growth, but the Human Cancer Genomics Database suggests that Fas can act as a tumor suppressor. In AOM-DSS-induced colon cancer and MCA-induced sarcoma mouse models, results showed that Fas is a tumor suppressor. In addition, Fas can also mediate the anti-tumor cytotoxic effect of tumor-specific cytotoxic T cells. Studies have reported that serum Fas levels are elevated in patients with cancer and autoimmune diseases, and the former may be derived from the tumor cells themselves.


    Human FAS Molecular Target Information


    Molecular name:FAS, Fas cell surface death receptor


    Also known as:

    • ALPS1A
    • APO-1
    • apo-1 antigen
    • APO-1 cell surface antigen
    • apoptosis antigen 1
    • apoptosis signaling receptor FAS
    • apoptosis-mediating surface antigen FAS
    • APT1
    • CD95
    • CD95 antigen
    • Delta Fas/APO-1/CD95
    • Fas (TNF receptor superfamily, member 6)
    • FAS 827dupA
    • Fas AMA
    • Fas antigen
    • FAS receptor variant 9
    • FAS1
    • FASLG receptor
    • FASTM
    • mutant tumor necrosis receptor superfamily member 6
    • RP11-399O19.9
    • TNF receptor superfamily member 6
    • TNFRSF6
    • tumor necrosis factor receptor superfamily member 6
    • tumor necrosis factor receptor superfamily, member 6

    Gene sequence:NCBI_Gene: 355

    Protein sequence:UniProtKB: P25445


    Human FAS target molecular function (prediction)


    Enables calmodulin binding activity; identical protein binding activity; and kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular protein metabolism process; and regulation of signal transduction. Acts upstream of or within apoptotic process. Located in several cellular components, including cell surface; membrane raft; and nuclear body. Part of CD95 death-inducing signaling complex. Implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hemat cancerologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and neurodegenerative disease (multiple).


    Mouse Fas molecular target information


    Molecular name:Fas, Fas (TNF receptor superfamily member 6)


    Alias:

    • AI196731
    • APO-1
    • CD95
    • expressed sequence AI196731
    • lpr
    • lymphoproliferation
    • TNF receptor superfamily member 6
    • TNFR6
    • Tnfrsf6


    Gene sequence:NCBI_Gene: 14102

    Protein sequence:


    Mouse Fas target molecular function (prediction)


    Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid gland system; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).


    Rat Fas molecular target information


    Molecular name: Fas, Fas cell surface death receptor

    Alias:

    • apo-1 antigen
    • apoptosis-mediating surface antigen FAS
    • CD95 antigen
    • Fas (TNF receptor superfamily, member 6)
    • Fas antigen (ATP1)
    • Fas receptor
    • FASLG receptor
    • Tnfrsf6
    • Tumor necrosis factor receptor superfamily, member 6
    • Tumor necrosis factor receptor superfamily, member 6

    Gene sequence:NCBI_Gene: 246097

    Protein sequence:


    Rat Fas target molecule function (prediction)


    Enables protease binding activity and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to estrogen stimulus; and nervous system development. Located in several cellular components, including apical dendrite; apical plasma membrane; and sarcolemma. Part of CD95 death-inducing signaling complex. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).