AOAH_MOUSE O35298
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UniProt:O35298
Recommended name:Acyloxyacyl hydrolase
EC number:EC 3.1.1.77
Alternative names:
Cleaved into:Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit
GeneID:27052
Gene names (primary ):Aoah
Gene names (synonym ):
Gene names (ORF ):
Length:574
Mass:65155
Sequence:MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSGRNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEEVFGDQGGH
Tissue specificity:Detected in peritoneal macrophages (at protein level) (PubMed:17322564, PubMed:28622363). Strongly expressed in kidney cortex, where it may be produced by proximal tubule cells (PubMed:15155618). In liver, expressed at high levels in Kupffer cells (PubMed:17322564). Expressed by dendritic cells (PubMed:12810692). Detected at low levels in alveolar macrophages (PubMed:28622363). {ECO:0000269|PubMed:12810692, ECO:0000269|PubMed:15155618, ECO:0000269|PubMed:17322564, ECO:0000269|PubMed:28622363}.
Induction:Strongly up-regulated in alveolar macrophages in response to bacterial lipopolysaccharides (LPS). {ECO:0000269|PubMed:28622363}.
Developmental stage:
Protein families: