NSUN2_MOUSE Q1HFZ0
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UniProt:Q1HFZ0
Recommended name：RNA cytosine C(5)-methyltransferase NSUN2
EC number：EC 2.1.1.-
Alternative names：(Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (mRNA cytosine C(5)-methyltransferase)(tRNA cytosine C(5)-methyltransferase)(EC 2.1.1.-)(EC 2.1.1.203)
Cleaved into：
GeneID：28114
Gene names (primary )：Nsun2
Gene names (synonym )：D13Wsu123e Misu
Gene names (ORF )：
Length：757
Mass：85452
Sequence：MGRRARGRRFQQPPQPEGEEDASDGGRKRGQAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWDQFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTVDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNKRQPKVQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGDSETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKTLLTQENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTLQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLGEKKKEGVILTNENAASPEQPGDEDAKQTAQDPCVPDSVPGCDAAAAEPSR
Tissue specificity：Ubiquitously expressed at low level (PubMed:16713953). Up-regulated in tumors (PubMed:16713953). Dynamically expressed during morphogenesis and in adult skin: in adult skin, expression is up-regulated in the bulge and hair germ as soon as the hair follicle enters its growing phase (anagen) (PubMed:22144916). During anagen, expressed at highest level in cells of the hair germ that give rise to the hair matrix (PubMed:22144916). {ECO:0000269|PubMed:16713953, ECO:0000269|PubMed:22144916}.
Induction：By Myc (at protein level). {ECO:0000269|PubMed:16713953}.
Developmental stage：Detected from E3.5 in the inner cell mass of the blastocyst (PubMed:22144916). Expressed throughout the extra-embryonic ectoderm, which gives rise to the nervous system and epidermis, after implantation and gastrulation (PubMed:22144916). Starting from E9.5, expression becomes more restricted and at E13.5 and E14.5 it is enriched in developing whiskers and eyes (PubMed:22144916). From E15.5, when the interfollicular epidermis begins to stratify and follicular morphogenesis starts by forming hair placodes, highest expression is observed in the suprabasal layer of interfollicular epidermis (PubMed:22144916). {ECO:0000269|PubMed:22144916}.
Protein families：Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family, TRM4 subfamily