Use at an assay-dependent concentration. For Sandwich ELISA pairing: Human CCL24/Eotaxin 2 Antibody(Detector) (EPA1580D), with Human CCL24/Eotaxin 2 Protein (EPA1580S) as assay standards. The reference range value is 7.8-2,000 pg/mL.
Target info
Function
Chemokine (C-C motif) ligand 24 (CCL24), also known as eotaxin-2 and myeloid progenitor inhibitory factor 2 (MPIF-2), encoded by the CCL24 gene on chromosome 7 in humans, is a CC-chemokine of the eotaxin subfamily. It is produced by activated monocytes, T lymphocytes, endothelial cells, and epithelial cells at sites of type 2 inflammation. CCL24 signals through the G-protein-coupled receptor CCR3, which is highly expressed on eosinophils and also on basophils and Th2 cells; receptor activation drives eosinophil and basophil chemotaxis, degranulation, and release of histamine and leukotriene C4. Although CCL24 shares limited sequence identity with CCL11/eotaxin-1, it is functionally redundant as an eosinophil chemoattractant and contributes to sustained eosinophil recruitment in asthma, allergic rhinitis, and atopic inflammation, acting alongside IL-5. CCL24 also suppresses colony formation by high-proliferative-potential myeloid progenitor cells and displays direct antimicrobial activity. CCL24 is a secreted chemokine that guides eosinophil and basophil trafficking to allergic tissues.
Subcellular Localization
Secreted.
UniProt
SwissProt: O00175 Human
Alias
C C motif chemokine 24 antibodyC-C motif chemokine 24 antibodyCCL24 antibodyCCL24_HUMAN antibodyChemokine CC Motif Ligand 24 antibodyCK beta 6 antibodyCK-beta-6 antibodyCkb6 antibodyEosinophil chemotactic protein 2 antibodyEotaxin-2 antibodyMPIF 2 antibodyMPIF-2 antibodyMPIF2 antibodyMyeloid progenitor inhibitory factor 2 antibodySCYA24 antibodySmall inducible cytokine A24 antibodySmall inducible cytokine subfamily A (Cys-Cys) member 24 antibodySmall-inducible cytokine A24 antibody
