KD-Validated TAR DNA Binding Protein Recombinant Rabbit Monoclonal Antibody-EnkiLife

KD-Validated TAR DNA Binding Protein Recombinant Rabbit Monoclonal Antibody

Summary

Production Name	KD-Validated TAR DNA Binding Protein Recombinant Rabbit Monoclonal Antibody
Description	KD-Validated antibody
Host	Rabbit
Application	WB,FCM,ICC,IHC-P
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	Rabbit IgG
Clonality	Rabbit mAb
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Purification	Affinity purification

Immunogen

Gene Name	TARDBP
Alternative Names	TARDBP; TAR DNA Binding Protein; TDP-43; ALS10; TAR DNA-Binding Protein 43; TAR DNA-Binding Protein-43; TDP43
Gene ID	23435
SwissProt ID	Q13148

Application

Dilution Ratio	WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200
Molecular Weight	Calculated MW: 44.7kDa

Background

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Research Area

Microbiology,Neuroscience,Epigenetics and Nuclear Signaling