KMT6 Rabbit Monoclonal antibody

Summary

Production Name	KMT6 Rabbit Monoclonal antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,ICC/IF
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification	Affinity Purified

Immunogen

Gene Name	EZH2
Alternative Names	WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
Gene ID	2146
SwissProt ID	Q15910

Application

Dilution Ratio	WB 1:500-1:1000,ICC/IF 1:50-1:200
Molecular Weight	Calculated MW: 85 kDa; Observed MW: 98 kDa

Background

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Research Area

Epigenetics and Nuclear Signaling