Summary
| Production Name | KO-Validated Neurofilament Medium Chain Recombinant Rabbit Monoclonal Antibody |
| Description | KD-Validated antibody |
| Host | Rabbit |
| Application | WB,FCM,ICC |
| Reactivity | Human,Rat |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | Rabbit IgG |
| Clonality | Rabbit mAb |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
| Purification | Affinity purification |
Immunogen
| Gene Name | NEFM |
| Alternative Names | NEFM; Neurofilament Medium Chain; NF-M; NFM; NEF3; Neurofilament, Medium Polypeptide 150kDa; Neurofilament Medium Polypeptide; Neurofilament Triplet M Protein; 160 KDa Neurofilament Protein; Neurofilament 3; Neurofilament, Medium Polypeptide; Neurofilament-3 (150 KD Medium); Neurofilament Medium |
| Gene ID | 4741 |
| SwissProt ID | P07197 |
Application
| Dilution Ratio | WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 |
| Molecular Weight | Calculated MW: 102.5kDa |
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Research Area
Neuroscience,Signal Transduction,Stem Cells,Developmental Biolopy