Use at an assay-dependent concentration. For Sandwich ELISA pairing: Mouse CCL5 Antibody(Capture) (EPA1586C), with Mouse CCL5 Protein (EPA1586S) as assay standards. The reference range value is 31.2-4,000 pg/mL.
Target info
Function
C-C motif chemokine ligand 5 (CCL5/RANTES), encoded by the Ccl5 gene in mice, is a pro-inflammatory CC chemokine orthologous to human CCL5. It is an approximately 8 kDa secreted protein produced by activated T lymphocytes, macrophages, platelets, fibroblasts, and endothelial cells. CCL5 is chemotactic for mouse monocytes, memory T cells, eosinophils, basophils, NK cells, and dendritic cells, recruiting these leukocytes to sites of infection and tissue injury. It signals through the G-protein-coupled receptors CCR1, CCR3, and CCR5 on target leukocytes, activating Gi-dependent phospholipase C, intracellular calcium mobilization, PI3K/Akt, and MAPK/ERK pathways that mediate integrin activation, cytoskeletal rearrangement, directed migration, and degranulation. It also engages the atypical decoy receptors ACKR1 and ACKR2 to shape and resolve chemokine gradients. In mouse models CCL5 contributes to antiviral and anti-tumor leukocyte recruitment, allograft rejection, allergic inflammation, and atherosclerotic plaque macrophage accumulation. CCL5 is a soluble secreted protein that associates with cell-surface heparan sulfate proteoglycans on endothelium to form tissue haptotactic gradients; it is not membrane-anchored and circulates in body fluids.
Subcellular Localization
Secreted.
UniProt
SwissProt: P30882 Mouse
Alias
Beta chemokine RANTES antibodyBeta chemokine RANTES precursor antibodyC C motif chemokine 5 antibodyCCL 5 antibodyCCL5 antibodyCCL5_HUMAN antibodyChemokine (C C motif) ligand 5 antibodyChemokine CC Motif Ligand 5 antibodyD17S136E antibodyEoCP antibodyEosinophil chemotactic cytokine antibodyMGC17164 antibodyRANTES(4-68) antibodyRegulated upon activation normally T expressed and presumably secreted antibodySCYA 5 antibodySCYA5 antibodySIS delta antibodySIS-delta antibodySISd antibodySmall inducible cytokine A5 (RANTES) antibodySmall inducible cytokine A5 antibodySmall inducible cytokine subfamily A (Cys Cys) member 5 antibodySmall-inducible cytokine A5 antibodyT cell specific protein p288 antibodyT cell specific protein RANTES antibodyT cell specific RANTES protein antibodyT cell-specific protein P228 antibodyT-cell-specific protein RANTES antibodyTCP 228 antibodyTCP228 antibody
